4.2. Assessment of IL-37 and SIGIRR Levels in BLCA versus Non-BLCA Lung Tissues

The TNMplot tool (www.tnmplot.com; accessed on 20 December 2022) [36] was used for the investigation of possible differential expression patterns of IL-37 and SIGIRR in BLCA tumors. RNA sequencing data deposited in The Cancer Genome Atlas (TCGA) database (https://www.cancer.gov/tcga; accessed on 29 December 2022) were processed for the comparative analysis of (a) 411 BLCA versus 30 non-BLCA individuals and (b) 19 pairs of BLCA versus adjacent normal tissue biopsies. The median and range of expression levels of each group, fold changes of the median between groups and the p-values of the non-parametric Mann–Whitney U test applied are reported; significant changes were considered those with p-values < 0.05 and fold changes >2 or <0.5.