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FY Fangshu Ye
CW Chong Wang
AO Annette M. O’Connor
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A previously published network of interventions for the treatment of Bovine Respiratory Disease (BRD) in feedlot cattle is used as an illustrative example for the problem of interest (O’Connor et al., 2016). The network comprises 98 trials and 13 treatments in total. Most trials contain two arms and eight trials contain three arms. The network plot is shown in Figure 1. Arm-level data are available and the outcome is a dichotomous health event. To compare treatments, the log odds ratios for pairwise comparisons are calculated.

An existing network of interventions for the treatments of Bovine Respiratory Disease (BRD) in feedlot cattle with a new study between CEFTH(A) and TRIM(B) where A and B had no direct comparison in the existing network.

We demonstrate the problem of inflated type I error risk using two simulation studies.

Copyright and License information:  ©2023 Ye, Wang and O’Connor.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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