Potential factors contributing to the discontinuation of denosumab

Factors that were potentially associated with denosumab adherence included age, sex, proximity to the medical center, prior anti-osteoporotic drug use, any recorded medication-related side effect experience, medical center classification (i.e., secondary or tertiary), malignancy history, rural-urban classification of residence (i.e., megalopolis/metropolitan city or village or city), financial burden of the treatment, number of prior hospitalizations, and the treatment provider’s medical specialty (i.e., an endocrinologist or another specialist). The financial burden of the treatment was determined based on whether the patients were health insurance subscribers or Medical Aid beneficiaries. A “no-show” was operationalized as an occasion when a patient missed his or her scheduled treatment appointment(s), interrupting the continuous denosumab treatment procedure.