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(1) Age from 29 days to 18 years; (2) The diagnostic criteria for AKI were according to KDIGO grading criteria, and PCIS was based on pediatric critical case score; (3) Vasoactive drug score (VIS) = dopamine+dobutamine+ 10 × milinone+ 100× epinephrine + 100× norepinephrine(ug/kg/min) -.

(1) Age ≤ 28 days or age ≥ 18 years old; (2) Kidney distance measured by ultrasound exceeds NIRS detection range; (3) Patients with chronic kidney dysfunction, underwent kidney surgery or renal vascular abnormalities, renal tumor, renal mass, renal dilatation, hydronephrosis, etc.; (4) Length of the stay less than 72 h; (5) Patient or parental refusal to participate in the study.

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