2.1. Animals and Ethical Considerations

All experiments were conducted in accordance with the Ethical Principles on Animal Research, adopted by the Brazilian College of Animal Experimentation (Colégio Brasileiro de Experimentação Animal, COBEA), and all procedures with animals were approved by the Ethics Committee on the Use of Animals (CEUA; #5172-1/2019) from the State University of Campinas (UNICAMP). In this work, C57BL/6 adult female mice (eight weeks old) were used. All mice were kept in regular filter-top cages, with free access to sterile food and water, and maintained in the animal facility of the Department of Genetics, Evolution, Microbiology and Immunology at UNICAMP.