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2.11 Immune correlation analysis

CF Chaoyou Fang
ZZ Zeyu Zhang
YH Yongquan Han
HX Houshi Xu
ZZ Zhengyang Zhu
YD Yichao Du
PH Pinpin Hou
LY Ling Yuan
AS Anwen Shao
AZ Anke Zhang
ML Meiqing Lou
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The correlation between URB2 expression and tumor mutational burden (TMB) was calculated by the Pearson correlation coefficient. The same calculation procedure was used for microsatellite instability (MSI) and tumor neoantigen burden (TNB). By analyzing the TIMER (https://cistrome.shinyapps.io/timer/) database, the relationship between URB2 expression and CD8 T-cells, B cells, macrophages, CD4 T-cells, dendritic cells, and neutrophils was determined. To explore the composition of the TME, we assessed the existence of infiltrating immune cells in glioma and calculated the ESTIMATEScore, which was estimated by expression data. To investigate the association between immunity and glioma progression, we profiled the expression of immune cells and immune checkpoints in glioma patients in TCGA datasets.

Copyright and License information:  ©2023 Fang, Zhang, Han, Xu, Zhu, Du, Hou, Yuan, Shao, Zhang and Lou.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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