Metabolic pathways were identified by utilizing open database sources of MBRole2.0 (http://csbg.cnb.csic.es/mbrole2/), including KEGG and HMDB. Compound names of the differential metabolites were first converted to KEGG IDs using MetaboAnalyst 5.0 and the KEGG IDs were submitted to MBRole 2.0 for KEGG pathway analysis.
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