2.3 CC-related target collection

{"type":"entrez-geo","attrs":{"text":"GSE74602","term_id":"74602"}}GSE74602 was selected from the GEO database (https://www.ncbi.nlm.nih.gov/geo/) as the study subject (Clough and Barrett, 2016). Differentially expressed genes were screened using GEO2R with adj.P.Val < 0.05, |logFC|>1 as screening criteria. The obtained differentially expressed genes were presented in volcano plots by TBtools (Chen et al., 2020). Some CC-related targets were obtained by searching the OMIM (https://www.omim.org/), DisGeNET (https://www.disgenet.org/), and GeneCards databases (https://www.genecards.org/) (Amberger et al., 2015; Stelzer et al., 2016; Piñero et al., 2020) using the search term “colon cancer”. The differentially expressed genes obtained from the GEO database were intersected with the CC-related targets obtained from these three databases to obtain CC disease-related targets.