All statistical analyses were performed using GraphPad Prism 7 (GraphPad Software, Inc., San Diego, CA, USA). Data are expressed as the mean ± standard deviation or as individual data points. Data were compared using Welch’s t-tests, Mann-Whitney U tests, Kruskal-Wallis tests, followed by Dunn’s multiple comparisons test, or two-way ANOVA followed by Tukey’s multiple comparison tests. Correlations between factors were evaluated using Spearman’s tests. Differences were considered statistically significant at p < 0.05.
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