IBM SPSS Statistics 23.0 software (Ehningen, Germany) was used for statistical analysis; Graph Pad Prism 3.0 (GraphPad Software, Inc., San Diego, USA) was applied for graphical illustrations. Since data were not normally distributed, the non-parametric Mann-Whitney-U-test was applied for group comparisons. Results are illustrated as scatter plots giving individual data. For sensitivity and specificity analyses, receiver operating characteristic (ROC) curves were calculated. Additionally, linear regression analysis was performed. P<0.05 was considered significant.
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