Patients

Three hundred and thirty-six LADCs that had been surgically resected (clinicopathological characteristics are presented in Table 1) and 177 LADC biopsy samples from inoperably advanced tumors (Table 2) were examined. These tumors were resected or biopsied between January 1997 and December 2013. Informed consent for the use of these samples for research purposes was obtained in writing. The ethics committees of Kanagawa Prefectural Cardiovascular and Respiratory Center and Yokohama City University approved the research plan.

EGFR, EGFR mutation; y/o, years old; n, number of cases; P-values were calculated using the Mann-Whitney test (Age) and the Fisher's exact test (other subjects); Asterisk(*), statistically significant

EGFR, EGFR mutation; y/o, years old; n, number of cases; P-values were calculated using the Mann-Whitney test (Age) and the Pearson x2 test (other subjects); Asterisk(*), statistically significant