Statistical analysis

Statistical analyses were performed using GraphPad Prism 10.0.1 software. Statistical comparison between groups was performed using the unpaired Student’s t-test, two-way analysis of variance with Tukey’s or Sidak’s correction, and Mann–Whitney test when indicated. A p-value less than 0.05 was considered statistically significant; ns indicates not significant. Statistical significance values were set as *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001. Data are presented as means ± standard error of the mean. p-value and n can be found in the main and supplementary figure legends.