Rank-rank hypergeometric overlap

GX Gengqiang Xie
MT Maria Pilar Toledo
XH Xue Hu
HY Hyo Jeong Yong
PS Pamela Sandoval Sanchez
CL Chengyang Liu
AN Ali Naji
JI Jerome Irianto
YW Yue J. Wang
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Rank–rank hypergeometric overlap (RRHO) is a threshold-free method aiming to compare gene expression profiles across two gene lists that were ranked by the degree of differential expression from two separate differential expression analyses [44]. The original RRHO method was further modified to improve the interpretability when the differential expression patterns are discordant in the two gene lists [45]. The input gene lists for RRHO were ranked by the log2FC (computed by limma-trend, see above) comparing the gene expressions of each endocrine cell type with all the other endocrine cell types in the snRNA-seq or scRNA-seq library.

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