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Utilities

CB Christian Bührer
TP Thomas Paling
RG Richard Gale
TP Tatiana Paulo
MB Marloes Bagijn
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Utility values (see Table ​Table4)4) are based on a study by Czoski-Murray et al. conducted in the UK which estimated a regression model to relate visual acuity score and utility on the basis of time trade-off methods, including an age covariate [40]. A further adjustment was applied to account for better vision in one eye, partially compensating for worse vision in the other. Aligned with the approach in a guideline review conducted by NICE in nAMD [20], a scaling factor of 0.3 is used to estimate the impact of changes in the worse seeing eye on utility. A disutility for injections and adverse events was included in the model. It was assumed that 50% of patients experience a total loss of quality of life on treatment days, informed by the same UK guideline [20].

Health state utility scores by visual acuity and first/second eye

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