Diagnosis of invasive breast cancer in the breast and axilla was histopathologically confirmed and defined according to WHO classification 9 . ER, PR, and HER2 statuses were evaluated by immunohistochemistry or fluorescence in situ hybridization before NAC administration. Tumor subtypes were defined as follows [12]: luminal A; ER(+) or PR(+), HER2-neu (–), Ki67 <20%; luminal B, ER(+) or PR(+), and/or HER2-neu (+), Ki67 ≥20%; non-luminal HER2-neu(+), ER(–) PR(–) HER2-neu (+); and triple-negative, ER(–) PR (–) HER2-neu (–).
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