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Subcortical nuclei

CS Charles H. Schleifer
KO Kathleen P. O’Hora
HF Hoki Fung
JX Jennifer Xu
TR Taylor-Ann Robinson
AW Angela S. Wu
LK Leila Kushan-Wells
AL Amy Lin
CC Christopher R. K. Ching
CB Carrie E. Bearden
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For each scan, volume was estimated for the whole thalamus, amygdala, and hippocampus, and their subregions using Bayesian methods to automatically segment T1w images using template atlases based on histological data and ultra-high-resolution ex vivo MRI [37–40]. These segmentations are well-validated and have been applied by multiple consortia to large scale neuroimaging analyses [41–45]. See Supplementary Fig. S2 for visualization of the FreeSurfer segmentation and Supplementary Methods for a list of all regions analyzed as well as details on segmentation, qualitative and statistical quality control (QC) procedures, and between-scanner harmonization using longitudinal ComBat [46].

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