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Reverse-direction MR analysis
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We were also concerned about whether these four IgG levels affect the abundance of gut microbial features in humans. We used the same settings as the above-mentioned MR analysis (P = 1.0E-5, r2 = 0.1, and window size = 1 Mb) to select IVs of four antiviral IgG levels (Fig. 1). In addition, we computed the sum of values of variance in phenotype explained (PVE) to assess the explanatory power of IVs, and computed the F statistics following reference to judge whether IVs are strong instruments [35].
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