2.6.3. GO and KEGG Enrichment Analyses

To perform the gene ontology (GO) analysis [58], the DEGs were mapped to GO terms in the gene ontology database (http://www.geneontology.org; accessed on 3 February 2023), and the significantly enriched GO terms were defined through the hypergeometric test and an adjusted p < 0.05. KEGG (Kyoto Encyclopedia of Genes and Genomes) [59] enrichment analysis was performed to further understand the biological functions of the DEGs and their interaction with each other in certain biological functions. Pathways with an adjusted p < 0.05 were defined as significantly enriched.