2.1.1. Screening of active compounds of XYS.

The components of the 8 herbs were identified using the pharmacology of Traditional Chinese Medicine Systems Pharmacology (TCMSP,https://tcmspw.com/tcmsp.php)^[14] and then screened based on their oral bioavailability (OB ≥ 30%) and drug-likeness (DL ≥ 0.18).^[15] TCMSP is a comprehensive platform for herbal medicines, containing information on 499 Chinese herbs registered in the Chinese pharmacopeia. It includes 29,384 ingredients, 3311 targets, and 837 associated diseases.^[16] The platform also offers additional data on chemicals, targets, and drug-target networks, such as drug similarity, oral bioavailability, and blood-brain barrier permeability.^[17] TCMSP aims to facilitate the development of herbal medicines and promote the integration of modern medicine and traditional medicine for drug discovery and development. The techniques employed in the TCMSP platform have been successfully used in previous studies to investigate the mechanisms of action of herbal medicines and TCM formulas in treating cardiovascular diseases and viral diseases.^[18]