Search strategy

All studies potentially investigating the haemodynamic effect of CBD (including BP, HR, and BF) were searched (until November 2016) in Medline, EMBASE, and PubMed. Search keywords included: Cannabidiol, Epidiolex, cardiovascular, blood pressure (BP), systolic, diastolic, hypertension, hypotension, heart rate (HR), tachycardia, bradycardia, blood flow (BF), haemodynamic, vasodilatation, vasorelaxation, and vasoconstriction. References from included studies were also hand searched. Initially, the National Institute for Health and Excellent Care platform was used in which two databases (EMBASE and Medline) were used for searching. Then, a separate search was conducted using PubMed. Pre-specified inclusion and exclusion criteria were used to prevent bias; studies had to be in vivo, assess haemodynamics (BP, HR, or BF), be original articles, and be a controlled study. The exclusion criteria were: in vitro studies, mixtures of CBD with other cannabis extracts, studies not assessing haemodynamics (BP, HR, or BF), review articles and editorials, or uncontrolled studies.