J. Protein Modeling and Molecular Dynamics Simulations

Koichiro Shimizu; Tadato Yonekawa; Morikatsu Yoshida; Mikiya Miyazato; Ayako Miura; Hideyuki Sakoda; Hideki Yamaguchi; Masamitsu Nakazato

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J. Protein Modeling and Molecular Dynamics Simulations

KS Koichiro Shimizu

TY Tadato Yonekawa

MY Morikatsu Yoshida

MM Mikiya Miyazato

AM Ayako Miura

HS Hideyuki Sakoda

HY Hideki Yamaguchi

MN Masamitsu Nakazato

This method is extracted from research article: J Endocr Soc, Sep 2017

Conformational Change in the Ligand-Binding Pocket via a KISS1R Mutation (P147L) Leads to Isolated Gonadotropin-Releasing Hormone Deficiency

DOI: 10.1210/js.2017-00277

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Protein structure modeling and molecular dynamics simulations were performed using the Molecular Operating Environment (version 2015.1001; Chemical Computing Group, Montreal, PQ, Canada). Homology models of wild-type KISS1R were generated based on the nociceptin receptor (Protein Data Bank code: 4EA3). The details of this method are provided in Supplemental Materials and Methods.

This article has been published under the terms of the Creative Commons Attribution Non-Commercial, No-Derivatives License (CC BY-NC-ND; https://creativecommons.org/licenses/by-nc-nd/4.0/).

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