To identify potential regulators of APOB expression in HCC, we searched for miRNAs that target APOB using StarBase, a database that integrates miRNA-target interactions from various sources (http://starbase.sysu.edu.cn/) [48, 49]. We then selected three miRNAs (hsa-miR-21-5p, hsa-miR-9-5p, and hsa-miR-877-5p) that were predicted to bind to APOB in more than three cancer types. Next, we investigated the possible lincRNAs that interact with these miRNAs using StarBase. We also performed expression correlation analyses between APOB, miRNAs, and lincRNAs in HCC samples from TCGA.
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