All data were analyzed using the Prism 8 software (GraphPad). For in vivo assays, the data are shown as mean ± SEM. For in vitro experiments, data are shown as mean ± SD. Statistical analysis was performed using unpaired or paired Student’s t-test and two-way ANOVA followed by Sidak’s multiple-comparisons test (*p < 0.05, **p < 0.01, ***p < 0.001).
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