2.2. Synthesis and characterization of poly(ortho ester amides) with amino groups in the side chains (POEAd-g-NH2)

POEAd-g-NH₂ was synthesized by condensation polymerization between 2,2′-((4,4′-(oxybis(methylene)) bis(1,3-dioxolane-4,2-diyl)) bis(oxy)) diethanamine (OEN) and Bis(2,5-dioxopyrrolidin-1-yl) O,O’-(2-(2,2,2-trifluoroacetamido) propane-1,3-diyl) disuccinate (BOD), and removal of trifluoroacetylation, as previously described [23]. The structure of POEAd-g-NH₂ was confirmed by hydrogen nuclear magnetic resonance (¹H NMR).