Synthesis of 3-methyl-1-(substituted benzyl or benzoyl)-6-(azole substituted-1-yl) pyrimidine-2,4(1H,3H)-dione derivatives (4a-4 l)

LE Leila Emami
FZ Fateme Zare
SK Soghra Khabnadideh
ZR Zahra Rezaei
ZS Zahra Sabahi
SG Saman Zare Gheshlaghi
MB Marzieh Behrouz
ME Mina Emami
ZG Zahra Ghobadi
SA Sedighe Madadelahi Ardekani
FB Fatemeh Barzegar
AE Ali Ebrahimi
RS Razieh Sabet
ask Ask a question
Favorite

Firstly, 1 mmol of the intermediate 2 or 3 was added to 1 mmol of various azole derivatives in the presence of 1 mmol of potassium carbonate and triethylamine in equal proportions and were refluxed at 75 °C for 24 h in acetonitrile as solvent. The progress of the reaction was controlled by TLC. The solvent was evaporated by rotary and extraction was done with ethyl acetate solvent. The organic part was collected and dehydrated with sodium sulfate, after filtration, the solvent was evaporated by rotary. Finally, the purification was conducted by plate chromatography. The final products of (4a-4l) were confirmed using 1HNMR, 13CNMR, MASS, and IR spectroscopic methods.

Do you have any questions about this protocol?

Post your question to gather feedback from the community. We will also invite the authors of this article to respond.

post Post a Question
0 Q&A