Study endpoints

The primary endpoint in START was a composite outcome with two major components: Serious AIDS-defining illnesses or death from AIDS, and serious non-AIDS illnesses (including cardiovascular, end-stage renal and liver diseases, non-AIDS defining cancers) or non-AIDS-related death. The specific conditions included in the serious AIDS and serious non-AIDS endpoints were described previously.¹ All reported events were reviewed by an endpoint review committee using pre-established criteria, blinded to the treatment group assignment.¹ Events that were adjudicated as confirmed or probable were included. Deaths were classified according to the CoDe system. ¹