Structure domain identification, data mining, and screening

Syed Umair Ahmad; Bushra Hafeez Kiani; Muhammad Abrar; Zainab Jan; Imran Zafar; Yasir Ali; Amer M. Alanazi; Abdul Malik; Mohd Ashraf Rather; Asrar Ahmad; Azmat Ali Khan

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Structure domain identification, data mining, and screening

SA Syed Umair Ahmad

BK Bushra Hafeez Kiani

MA Muhammad Abrar

ZJ Zainab Jan

IZ Imran Zafar

YA Yasir Ali

AA Amer M. Alanazi

AM Abdul Malik

MR Mohd Ashraf Rather

AA Asrar Ahmad

AK Azmat Ali Khan

This method is extracted from research article: J Infect Public Health, Jul 2022

A comprehensive genomic study, mutation screening, phylogenetic and statistical analysis of SARS-CoV-2 and its variant omicron among different countries

DOI: 10.1016/j.jiph.2022.07.002

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The Omicron sequence was aligned with Delta and Omicron isoform variations using bioinformatics software. The alignment illustration was created using the box shading tool. For the identification of conserved domains in intact elements, the nucleotide sequences were considered in the conserved domain database (CDD) of NCBI (http://www.ncbi.nlm.nih.gov/Structure/cdd/cdd.shtml) with default parameters. Conventional data mining approaches were used in CDD to retrieve conserved domains from the SARS-CoV-2 and Omicron sequence in different countries for further investigation. Coronanucleoca and DUF5515 were the domains that were targeted for these elements.

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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