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The parameter fluxwt represents wild-type flux that is the flux solution of the wild-type model, and fluxopt represents the optimum flux that is the flux solution of the theoretical maximum yield model. The up-regulation ratio (Ratio) is defined as the ratio of fluxopt to fluxwt of a reaction (Ratio = fluxopt / fluxwt). And the Yield is simulated product yield of the targeted product by using fluxopt of a reaction as the constraint, in which maximizing cell growth is the objective function.
Copyright and License information: ©2017 The Author(s)
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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