This meta-analysis followed the Preferred Reporting Items for Systematic and Meta-Analysis (PRISMA) Statement, and it was registered on PROSPERO (number CRD42020163104). We searched for studies evaluating the efficacy of combination antibiotic therapies for treating MSSA bacteremia compared to monotherapy.
A health sciences librarian conducted the search by using subject headings and keywords for Ovid MEDLINE, EMBASE, and Cochrane CENTRAL (Wiley) from database inception until 29 January 2021 (Supplementary material). We searched clinicaltrials.gov to detect unpublished studies. The reference lists of included articles were reviewed to identify additional studies.
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