For preclinical study, all data are presented as mean ± standard error of mean (SEM). Statistical analyses were performed using GraphPad Prism 8 software. Each continuous variable was analyzed for a normal distribution using the Kolmogorov–Smirnov test, and then statistical analysis was performed using a two-tailed Student’s t-test or one-way ANOVA assay with Dunnett post-hoc test if F was less than 0.05 and there was no significant variance inhomogeneity. Differences were considered significant at *p < 0.05, **p < 0.01, ***p < 0.001.
For clinical study, data are median or n (%). p values were calculated by Mann–Whitney test. Differences were considered significant at *p < 0.05.
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