5.2. Integrated meta-analysis of HCC and mouse genes

All probes were mapped to the gene ID in the Ensembl database (https://www.ensembl.org, build 92), and mouse Ensembl gene IDs were then mapped to human Ensembl gene IDs [88]. An average ratio was calculated for the multiple probes mapped into one Ensembl gene ID. For all tumor/normal ratios, log2 transformations were performed, followed by the Z-score transformation of each sample to standardize data across samples in all datasets [89]. Student’s t-test was performed for each Ensembl gene ID.