2. Histopathological review

We retrieved the original diagnoses from the archived hysterectomy specimen data with matched curettage specimens if could, because sometimes tumor tissue was mostly in the curettage specimen but not hysterectomy specimen. Two additional gynecological pathologists then reviewed the hematoxylin and eosin-stained slides and reassigned the tumor histological type and grade. We limited our study to specimens with endometrioid carcinoma (grade 3), serous carcinoma, clear cell carcinoma, mixed carcinoma, undifferentiated and dedifferentiated carcinoma, and carcinosarcoma. Each pathologist was blind to the original diagnosis and to the other pathologist’s interpretation. Discrepant cases were examined under a multi-head microscope by more than 2 pathologists to arrive at a consensus.