Optimal Prognostic Cut-Off Values for D-Dimer and PF

The mean D-dimer and PF levels were 0.56 µg/mL (SD, ± 0.18) and 3.44 g/L (SD, ± 1.96), respectively. According to the findings of the receiver operating characteristic curve (ROC) analysis, the optimum cut-off values were 0.46 µg/mL for preoperative D-dimer ( Figure 1A ) and 3.34 mg/mL for preoperative PF ( Figure 1B ). The maximum area under the curve (AUC) values for the ROC curves corresponding to D-dimer and PF were 0.720 (95% CI 0.639 to 0.791) and 0.697 (95% CI 0.615 to 0.771), respectively.

ROC curve analysis for determination of optimal cut-off values of D-dimer (A) and PF (B) levels in 5-year OS.

The sensitivities of D-dimer and PF were 0.854 and 0.855, respectively, while the specificities were 0.626 and 0.627, respectively. According to the optimal cut-off values for D-dimer and PF, the patients were divided into the following groups: high PF group (> 3.34 mg/mL; n = 84) and low PF group (≤ 3.34 mg/mL; n = 61) and high D-dimer group (> 0.46 µg/mL; n = 95) and low D-dimer group (≤ 0.46 µg/mL; n = 50).