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Preparation of RODD and solvent
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Ropivacaine 36.5 g was added to benzyl alcohol 100.8 g and benzyl benzoate 405.5 g, then heated, and stirred. After the ropivacaine was dissolved, soybean oil 651.3 g were added to the ropivacaine solution. Then, the mixture was stirred until the solution clear. After sterile filtration with filter, the bulk solution of RODD 30 mg/mL was obtained. The RODD was diluted with solvent to 9 mg/mL. The solvent was prepared with the same procedure without ropivacaine.
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