The serum proteomic data was derived from a large population-based study (AGES Reykjavik study; n = 5457) [16]. The AGES Reykjavik study consisting of predominantly European individuals older than 65 years of age, whose phenotype and genotype information were available. The Slow-Off rate Modified Aptamer (SOMAmer), a proteomic profiling platform, was used to determine the serum levels of 4137 human proteins.
The whole-blood eQTL data was derived from the Genotype-Tissue Expression (GTEx) version 6 database (n = 338) [17]. The gene expression data was obtained using paired-end RNA-seq (Illumina TruSeq; Illumina Inc) and the genotype data was from whole-genome sequencing. Full descriptions of donor registration, consent process, biological sample acquisition methods, sample attachment and histopathological examination procedures are available on the official GTEx website [18].
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