Statistical Analyses

All statistical analyses were performed with the GraphPad Prism software (version 8.3.0, RRID:SCR_003070). For all in-vitro experiments 3 biological replicates were used for analysis and appropriate two-way ANOVA tests with Bonferroni correction were conducted with p<0.05 being considered as significant except where stated otherwise. For in-vivo xenograft experiments a standard t-test with Bonferroni correction on the final day of measurement was conducted via GraphPad Prism.

Additional experimental reagents are supplied in supplementary methods.