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Inadequate responders after 4-week EPO treatment will be randomly assigned to one of three study treatment groups at a 1:1:1 ratio. A stratified block randomisation with randomly varying block size will be performed, stratified according to study site, cisplatin-containing chemotherapy (yes vs no) and iron deficiency status at baseline (absolute vs functional). Random assignment is generated by a statistician from Shanghai Knowlands MedPharm Consulting Co, and implemented via random envelopes assigned to each site. In order to avoid potential selection bias, the sequence is concealed from both clinical staff and patients until assignment. Hence, neither investigators nor participants can influence which group the patients are assigned to.
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