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Statistical analysis

AA Alexander Appelstrand
FB Fredrik Bergstedt
AE Anna-Karin Elf
HF Henrik Fagman
PH Per Hedenström
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Descriptive, continuous data were described as median and interquartile range (IQR), while descriptive, categorical data were described as frequencies.

In the calculation of the diagnostic sensitivity of EUS-FNB, an intention-to-diagnose analysis was performed.

Fisher’s exact test was used in the proportional analysis of any factors with a potential impact on the sampling yield and biopsy quality of EUS-FNB.

Pearson’s test was used to calculate the correlation coefficient (r-value) between the Ki-67 Index as in EUS-FNB samples and as in surgical specimens. Additionally, Wilcoxon signed rank test was used to identify any difference in the Ki-67 Index comparing EUS-FNB samples and their corresponding surgical specimens.

Cohen’s kappa value was calculated to describe the level of agreement comparing PanNET grading in EUS-FNB samples and PanNET grading in the corresponding surgical specimens. Both an intention-to-diagnose analysis and a per-protocol analysis was performed.

A p-value of < 0.05 was considered statistically significant in all analyses. The statistical calculations and tests were performed using IBM SPSS Statistics version 25.0.

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