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By analyzing the distinguishing feature of studies included in this meta-analysis, two subgroup analyses were implemented as below: 1. different doses of esketamine; 2. different ways of administration of esketamine. Dosage of intranasal esketamine was divided into 28 mg, 56 mg and 84 mg and dosage of intravenous esketamine was divided into 20 mg/kg and 40 mg/kg. Different ways of administration can be intranasal and intravenous.
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