After a thorough physical examination and a review of clinical history, each candidate underwent the supine head-turning test or Dix-Hallpike test. In most cases (about 90%), BPPV was involved with the posterior semicircular canal, and most patients were diagnosed with canalithiasis type. Thus, only the canalithiasis type of BPPV patients involved with the posterior semicircular canal in this study. Sixty patients who were included were randomly assigned to two groups. One group was treated with Betahistine (12 mg/time, 3 times/day); the other group was treated with placebo. This treatment was continued for 4 weeks. Blood samples were then drawn at the end of 4 weeks. All patients signed an informed consent form approved by the second affiliated hospital of air force medical university Institutional Review Board prior to the first blood sampling.
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