Types of additional outcome measures

Additional outcome measures will include patient-reported physical-specific symptoms, such as fatigue and sleep. Data will be synthesised if fatigue was measured by such instruments as Brief Fatigue Inventory, Multidimensional Fatigue Symptom Inventory-Short Form, Fatigue Symptom Inventory, Functional Assessment of Chronic Illness Therapy-Fatigue, Piper Fatigue Scale and Multidimensional Fatigue Inventory; and sleep quality was assessed by Pittsburgh Sleep Quality Index, General Sleep Disturbance Scale or other scales. Patients’ psychological-specific symptoms will be analysed if they were assessed by Depression Anxiety Stress Scale-21, Beck Depression Inventory, Center for Epidemiologic Studies Depression, Profile of Mood State or other scales. Safety data (ie, adverse events) of the QTC intervention will be descriptively reported.