A total sample size of 542 preterm neonates was obtained using STATA version 14 statistical software based on the cox-proportional hazard regression, taking a Crude Hazard Ratio (CHR) of different predictors such as home delivery (CHR = 2.14), hyaline membrane disease (CHR = 4.38), KMC (CHR = 0.41), crying immediately after birth (CHR = 0.25) and hypoglycemia (CHR = 2.1) as effect size (20), 5% marginal error, a standard error of 0.5, study power of 80% and a reasonable estimate for the proportion of preterm mortality from the prior study was 28.8% (25). Meanwhile, to check the adequacy of the sample size used, a post-hoc power analysis was computed and the sample size was adequate to represent the study population with post-hoc power value of 90%.
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