3.2.3. Nitro Reduction with Sodium Dithionite A2b

To a solution of nitro compound (1 eq.) in 1,4-dioxane/water (5:1, v/v), sodium dithionite (4 eq.) and sodium bicarbonate (10 eq.) were added. The heterogeneous mixture was stirred vigorously under reflux until the complete consumption of the nitro compound. The salts were filtered off and 1,4-dioxane evaporated. The organic compounds were transferred in a separation funnel with EA and H₂O, extracted twice with EA, washed with brine, and dried over Na₂SO₄. After evaporation, the crude product was purified by flash chromatography.