TIDE is an effective algorithm that integrates two mechanisms of tumor immune escape—T-cell dysfunction and T-cell exclusion, which could be useful to predict immune checkpoint inhibitor (ICI) response in cancer treatment. The TIDE online web (http://tide.dfci.harvard.edu) was used to calculate the TIDE score, MSI score, T-cell exclusion score, and T-cell dysfunction score with the normalized RNA-seq data.
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