STRING database (ELIXIR, Hinxton, Cambridge shire, UK) were utilized for the protein-protein interaction (PPI) network construction, based on the methylation and expression of inversely correlated genes. Network Analyzer (http://www.mpi-inf.mpg.de/) was used to determine the topological properties of the biological networks. Cytoscape software (Institute for Systems Biology, Seattle, WA, USA) was used for network visualization.
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