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The review included double-blinded, randomized controlled trials (RCTs), published in any language, comparing a combination of 2 or more nonopioid analgesics to at least one of the combination's individual components and/or placebo in reducing cancer-related pain. Both parallel and crossover study designs were considered. Nonrandomized and/or nonblinded studies were excluded.
Copyright and License information: ©2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The International Association for the Study of Pain.
This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
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