Variables

Patient age, gender, ethnicity, and body mass index were collected and included in the analysis. Comorbidities comprised the following conditions: hypertension, diabetes, cardiovascular, pulmonary, neurological or hepatic diseases, current or previous neoplasia, and autoimmune disease. The following clinical presentation parameters were also included in the analysis: fever and/or chills, cough, dyspnea, myalgia, diarrhea, headache, fatigue and or/asthenia, runny nose, and nausea and/or vomiting. Data related to KT such as donor source, end-stage kidney disease (ESKD) etiology, time after transplantation, baseline renal function, maintenance immunosuppressive (IS) drugs, steroid (ST) pulse therapy <3 months, use of rabbit antithymocyte globulin (rATG) <3 months were analyzed.

The following laboratory exams at admission were recorded: lymphocytes count, hemoglobin, platelets count, C-reactive protein, lactic dehydrogenase, aspartate transaminase; alanine transaminase; creatine phosphokinase, serum sodium, ferritin, serum creatinine. Chest radiography and/or computed tomography at admission were used to classify pulmonary abnormalities.

The following treatments available in the registry were analyzed: antibiotics, particularly azithromycin, high-dose steroids, prophylactic or therapeutic use of anticoagulants, and use of oseltamivir, ivermectin, and chloroquine or hydroxychloroquine.

The analysis of outcomes in COVID-19 transplant recipients across time was carried out considering fatality rates and the following variables: invasive mechanical ventilation, intensive care unit admission, and development of AKI with dialysis requirement.