The chemicals, such as ZnCl2 (Cat#10023818), Zn(CH3COO)2 (Cat#30192618), and ZnSO4 (Cat#10024018) were obtained from Sinopharm Chemical Reagent Co, Ltd. (Shanghai, China). Compounds, 48/80 (Cat#C2313) and chloroquine (Cat#C6628) were obtained from Sigma-Aldrich (St. Louis, MO, USA). Pyrithione (Cat# HY-B1747-10 mg) and Clioquinol (Cat# HY-14603) were obtained from MCE (MedChemExpress, New Jersey, USA). TPEN (Cat#4309/100), (Cat#2896), A967079 (Cat#4716), capsazepine (CPZ, Cat#0464), HC067047 (Cat#4100), and U0126 (Cat#U120) were obtained from Tocris (Bristol, UK). Morphine hydrochloride was obtained from China Northeast Pharmaceutical Group Shenyang No. 1 Pharmaceutical CO., Ltd (Shenyang City, Liaoning Province, China). Naloxone hydrochloride was obtained from China Sinopharm Group Guorui Pharmaceutical CO., Ltd (Huainan City, Anhui Province, China). TPEN, pyrithione, and clioquinol were dissolved in 10% dimethyl sulfoxide (DMSO). Unless otherwise specified, other reagents are dissolved in sterile saline. HC030031
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