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Linear regressions stratified by genotyping array (UKBB, UKBL) were performed for each mtDNA SNP on the 41 traits and mtDNA-CN, including the following covariates: age, age2, sex, center, first 20 genotyping PCs. Only SNPs with MAF > 0.005 and imputation INFO score > 0.80 were included (UKBB, n = 223; UKBL, n = 190; both, n = 149). Results were then meta-analyzed using inverse variance weighting.
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