Criteria for considering studies for the review

Study population: studies involving adults (age ≥18 years) living in LMICs.

Intervention type: studies reporting on interventions for either primary or secondary prevention of CVD.

Setting: primary (randomised control trials and observational studies) or modelling studies conducted in LMICs.

Comparator: studies identifying how the interventions were compared, either with respect to current practice or the ‘do nothing’ scenario.

Outcome measures: the outcomes of interest would be: cost per life year gained or per unit clinical outcome, cost per quality-adjusted life years (QALYs) or cost per DALYs.

Study designs: studies reporting full economic evaluations (cost-effectiveness analysis (CEA), cost-benefit analysis (CBA), cost-utility analysis (CUA)) shall be considered. This would include empirical as well as modelling studies.

Language: studies reported in English and French.

Study setting: any studies conducted in high-income countries and duplicate publications of the same material will be excluded. If a study has been published in more than one journal, only the most complete and recent version will be considered.

Study types: narrative reviews, letters to the editor, case reports, editorials or any other lacking explicit information and methods will be excluded.